#BETA BLOCKER ANTIDOTE GLUCAGON MOA FULL#

During its withdrawal the patient should be kept under close surveillance.Īlthough cardioselective beta blockers may have less effect on lung function than non selective beta blockers these should be avoided in patients with reversible obstructive airways disease unless there are compelling clinical reasons for their use. The patient may be protected against vagal reactions by intravenous administration of atropine. If treatment is continued, caution should be observed with the use of certain anaesthetic drugs. Continuation of beta-blockade reduces the risk of arrhythmias during induction and intubation, however the risk of hypertension may be increased as well. When it has been decided to interrupt a beta-blockade in preparation for surgery, therapy should be discontinued for at least 24 hours. In addition, hypertension and arrhythmias may develop.

If necessary, at the same time, initiating replacement therapy, to prevent exacerbation of angina pectoris. When possible, metoprolol should be withdrawn gradually over a period of 10 days, the doses diminishing to 25mg for the last 6 days. In patients with significant hepatic dysfunction dosage reduction may be advised.ĭose adjustment is not warranted in renal impairment.Ībrupt cessation of therapy with a beta-blocker should be avoided especially in patients with ischaemic heart disease. Metoprolol tartrate is not recommended in children. The safety and efficacy of Metoprolol in children has not been established. Dosage should be reduced in the elderly where there is impairment of hepatic function. However, caution is indicated in elderly patients as an excessive decrease in blood pressure or pulse rate may cause the blood supply to vital organs to fall to inadequate levels. There is no evidence to suggest that dosage requirements are different in otherwise healthy elderly patients. The optimum dose should be individually determined according to clinical response. Dose should be reduced progressively as euthyroid state is achieved.ġ00 - 200 mg daily in divided doses (morning and evening). The treatment should be continued for at least 3 months.ĥ0mg four times daily. The usual maintenance dose is 200 mg daily given in divided doses. dose should be given half the suggested oral dose.

#BETA BLOCKER ANTIDOTE GLUCAGON MOA FULL#

Patients who fail to tolerate the full i.v. Orally, therapy should commence 15 minutes after the last intravenous injection with 50mg every 6 hours for 48 hours and preferably within 12 hours of the onset of chest pain. The initial oral dose should not exceed 50mg twice daily. If necessary the dose may be increased to 300mg daily in divided doses.įollowing the treatment of an acute arrhythmia with metoprolol tartrate injection, continuation therapy with metoprolol tablets should be initiated 4-6 hours later. In general a significant improvement in exercise tolerance and reduction of angina attacks may be expected with a dose of 50-100mg twice daily.ĥ0mg two or three times daily is usually sufficient. Usually 50-100 mg two or three times daily. In the latter type of patient the previous therapy may be continued and metoprolol added in to the regime with adjustment of the previous therapy if necessary. Metoprolol may be administered with benefit both to previously untreated patients with hypertension and to those in whom the response to previous therapy is inadequate.

Combination therapy with a diuretic or vasodilator may also be considered to further reduce blood pressure. This may be increased, if necessary, to 200mg daily in single or divided doses. The following dosage regimes are intended only as a guideline and should always be adjusted to the individual requirements of the patient but should not exceed 400 mg/day. Date of first authorisation/renewal of the authorisation 6.6 Special precautions for disposal and other handling.4.7 Effects on ability to drive and use machines.4.5 Interaction with other medicinal products and other forms of interaction.4.4 Special warnings and precautions for use.4.2 Posology and method of administration.Show table of contents Hide table of contents

Beta blocker antidote glucagon moa